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38 μM for IDH1R132H
28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5
3-dihydro-1H-indene-5-sulfonyl)urea
5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate
InChiKey: ZMXRHHJWXLKMTL-UHFFFAOYSA-N
K777 Catalog No.:M33083-C 38 μM for IDH1R132HK777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad spectrum antiviral by targeting cathepsin mediated cell entry. K777 inhibits SARS CoV and EBOV pseudovirus entry